diff --git a/workflow/engine/content/translations/english/processmaker.en.po b/workflow/engine/content/translations/english/processmaker.en.po
index 24b73383c..30091b7e5 100755
--- a/workflow/engine/content/translations/english/processmaker.en.po
+++ b/workflow/engine/content/translations/english/processmaker.en.po
@@ -26063,6 +26063,12 @@ msgstr "You must login again to view the changes. Do you want do it now?"
 msgid "System Settings"
 msgstr "System Settings"
 
+# TRANSLATION
+# LABEL/ID_SYSTEM_VARIABLES_ARE_PROTECTED
+#: LABEL/ID_SYSTEM_VARIABLES_ARE_PROTECTED
+msgid "System variables are protected from changes, this request is denied"
+msgstr "System variables are protected from changes, this request is denied"
+
 # TRANSLATION
 # LABEL/ID_TABLE
 #: LABEL/ID_TABLE
diff --git a/workflow/engine/data/mysql/insert.sql b/workflow/engine/data/mysql/insert.sql
index df46a9d18..ad4443d74 100755
--- a/workflow/engine/data/mysql/insert.sql
+++ b/workflow/engine/data/mysql/insert.sql
@@ -61281,6 +61281,7 @@ INSERT INTO TRANSLATION (TRN_CATEGORY,TRN_ID,TRN_LANG,TRN_VALUE,TRN_UPDATE_DATE
 ( 'LABEL','ID_SYSTEM_INFO','en','System information','2014-01-15') ,
 ( 'LABEL','ID_SYSTEM_REDIRECT_CONFIRM','en','You must login again to view the changes. Do you want do it now?','2015-01-16') ,
 ( 'LABEL','ID_SYSTEM_SETTINGS','en','System Settings','2014-01-15') ,
+( 'LABEL','ID_SYSTEM_VARIABLES_ARE_PROTECTED','en','System variables are protected from changes, this request is denied','2022-03-24') ,
 ( 'LABEL','ID_TABLE','en','Table','2014-01-15') ,
 ( 'LABEL','ID_TABLES_REMOVED_SUCCESSFULLY','en','tables removed Successfully','2014-01-15') ,
 ( 'LABEL','ID_TABLES_REMOVED_WITH_ERRORS','en','tables removed but with errors','2014-01-15') ,
diff --git a/workflow/engine/src/ProcessMaker/BusinessModel/Cases.php b/workflow/engine/src/ProcessMaker/BusinessModel/Cases.php
index a160091da..c13d0cb80 100644
--- a/workflow/engine/src/ProcessMaker/BusinessModel/Cases.php
+++ b/workflow/engine/src/ProcessMaker/BusinessModel/Cases.php
@@ -1972,6 +1972,13 @@ class Cases
         Validator::isArray($app_data, '$app_data');
         Validator::isString($usr_uid, '$usr_uid');
         Validator::usrUid($usr_uid, '$usr_uid');
+        // Validate the system variables
+        $systemVars = G::getSystemConstants();
+        foreach ($systemVars as $key => $var) {
+            if (array_key_exists($key, $app_data)) {
+                throw new Exception(G::LoadTranslation("ID_CAN_NOT_CHANGE"));
+            }
+        }
 
         $arrayResult = $this->getStatusInfo($app_uid);